GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6978712 | 1 | rs6962032 | chr7:127151489 | GRM8 | chr7:126078652-126893147:- | -0.35 | -3.6 | 0.000351 | Medication adherence in chronic diseases |
| THCA | cis | rs6963495 | 1 | rs6963495 | chr7:105166853 | RINT1 | chr7:105172532-105208124:+ | -0.25 | -3.68 | 0.000256 | Bipolar disorder (body mass index interaction) |
| THCA | cis | rs875971 | 1 | rs6963646 | chr7:65685767 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.22 | 2.88E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6963646 | chr7:65685767 | GUSB | chr7:65425675-65447246:- | -0.28 | -5.43 | 8.96E-8 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6963646 | chr7:65685767 | LOC729156 | chr7:66274980-66309813:- | -0.16 | -3.37 | 0.0008 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6963646 | chr7:65685767 | RABGEF1 | chr7:66093890-66276446:+ | -0.65 | -13.95 | 2.4E-37 | Aortic root size |
| THCA | cis | rs2243480 | 1 | rs6964245 | chr7:65718717 | CCT6P1 | chr7:65216092-65228661:+ | -0.44 | -6.89 | 1.74E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6964245 | chr7:65718717 | CRCP | chr7:65579805-65619551:+ | 0.3 | 4.52 | 7.98E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6964245 | chr7:65718717 | RABGEF1 | chr7:66093890-66276446:+ | -0.59 | -7.26 | 1.54E-12 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6964530 | chr7:65718851 | CCT6P1 | chr7:65216092-65228661:+ | -0.44 | -6.8 | 3.23E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6964530 | chr7:65718851 | CRCP | chr7:65579805-65619551:+ | 0.3 | 4.57 | 6.18E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6964530 | chr7:65718851 | RABGEF1 | chr7:66093890-66276446:+ | -0.59 | -7.23 | 1.92E-12 | Diabetic kidney disease |
| THCA | cis | rs6465657 | 1 | rs6965016 | chr7:97807882 | BRI3 | chr7:97910979-97922275:+ | -0.11 | -4.02 | 6.89E-5 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6965016 | chr7:97807882 | TECPR1 | chr7:97846060-97881468:- | -0.13 | -3.72 | 0.000225 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs2730245 | 1 | rs6965685 | chr7:158726462 | ESYT2 | chr7:158523689-158622319:- | 0.12 | 3.43 | 0.000659 | Height |